Hematological toxicities in patients with newly diagnosed glioblastoma on concurrent radiation and temozolamide-single institution experience
نویسندگان
چکیده
منابع مشابه
Survival in patients with newly diagnosed conventional glioblastoma: a modified prognostic score based on a single-institution series.
AIMS AND BACKGROUND Recursive partioning analysis (RPA) is commonly used to define the stratification of patients with glioblastoma. Epigenetic silencing of the O6-methylguanine methyltransferase (MGMT) gene by promoter methylation plays an important role in regulating MGMT expression in gliomas and this is an established independent prognostic factor. We tested a prognostic scoring system incl...
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AIMS AND BACKGROUND To report our experience of patients with primary glioblastoma multiforme of young age by evaluating the characteristics, prognostic factors, and treatment outcomes. PATIENTS AND METHODS Seventy patients with primary glioblastoma multiforme (GBM) treated at our department between 1996 and 2004 were studied. The male-female ratio was 2.6:1. The median age was 53 (16-74). Si...
متن کاملCancer Therapy: Clinical Concurrent Temozolomide and Dose-Escalated Intensity-Modulated Radiation Therapy in Newly Diagnosed Glioblastoma
Purpose: To determine the maximum-tolerated dose (MTD) of radiation (RT) with concurrent temozolomide in patients with newly diagnosed glioblastoma (GBM), to estimate their progression-free (PFS) and overall survival (OS), and to assess the role of C methionine PET (MET-PET) imaging in predicting
متن کاملConcurrent temozolomide and dose-escalated intensity-modulated radiation therapy in newly diagnosed glioblastoma.
PURPOSE To determine the maximum-tolerated dose (MTD) of radiation (RT) with concurrent temozolomide in patients with newly diagnosed glioblastoma (GBM), to estimate their progression-free (PFS) and overall survival (OS), and to assess the role of (11)C methionine PET (MET-PET) imaging in predicting recurrence. EXPERIMENTAL DESIGN Intensity-modulated RT (IMRT) doses of 66 to 81 Gy, assigned t...
متن کاملConditional probability of survival in patients with newly diagnosed glioblastoma.
PURPOSE The disease outcome for patients with cancer is typically described in terms of estimated survival from diagnosis. Conditional probability offers more relevant information regarding survival for patients once they have survived for some time. We report conditional survival probabilities on the basis of 498 patients with glioblastoma multiforme receiving radiation and chemotherapy. For 1...
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ژورنال
عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
سال: 2014
ISSN: 0317-1671,2057-0155
DOI: 10.1017/cjn.2014.92