Helix-Helix Interactions: Is the Medium the Message?
نویسندگان
چکیده
منابع مشابه
Ion-mediated nucleic acid helix-helix interactions.
Salt ions are essential for the folding of nucleic acids. We use the tightly bound ion (TBI) model, which can account for the correlations and fluctuations for the ions bound to the nucleic acids, to investigate the electrostatic free-energy landscape for two parallel nucleic acid helices in the solution of added salt. The theory is based on realistic atomic structures of the helices. In monova...
متن کاملMapping the energy surface of transmembrane helix-helix interactions.
Transmembrane helices are no longer believed to be just hydrophobic segments that exist solely to anchor proteins to a lipid bilayer, but rather they appear to have the capacity to specify function and structure. Specific interactions take place between hydrophobic segments within the lipid bilayer whereby subtle mutations that normally would be considered innocuous can result in dramatic struc...
متن کاملCommentary Helix is a helix is a helix ?
There is much activity directed at quantifying the contribution of specific interactions to the stabilization of protein structure. The paper by Myers et al. (1) in this issue of the Proceedings addresses a central and much studied issue: The experimental measure of the intrinsic a-helix forming propensities of the amino acids. What is an intrinsic a-helix forming propensity? The idea that the ...
متن کاملThe affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication.
Sequence motifs are responsible for ensuring the proper assembly of transmembrane (TM) helices in the lipid bilayer. To understand the mechanism by which the affinity of a common TM-TM interactive motif is controlled at the sequence level, we compared two well characterized GXXXG motif-containing homodimers, those formed by human erythrocyte protein glycophorin A (GpA, high-affinity dimer) and ...
متن کاملPredicting helix–helix interactions from residue contacts in membrane proteins
MOTIVATION Helix-helix interactions play a critical role in the structure assembly, stability and function of membrane proteins. On the molecular level, the interactions are mediated by one or more residue contacts. Although previous studies focused on helix-packing patterns and sequence motifs, few of them developed methods specifically for contact prediction. RESULTS We present a new hierar...
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ژورنال
عنوان ژورنال: Structure
سال: 2015
ISSN: 0969-2126
DOI: 10.1016/j.str.2015.02.004