Helicobacter pylori infection contributes to the expression of Alzheimer's disease-associated risk factors and neuroinflammation
نویسندگان
چکیده
Over time, mounting evidence has demonstrated extra-gastric manifestations of Helicobacter pylori infection. As such, a number studies the potential contribution H. infection to incidence and progression Alzheimer's disease (AD). Considering unanswered questions regarding effect on brain activity, we sought investigate impact expression AD-associated risk factors. We used two clinical strains obtained from patients with peptic ulcer evaluated their influence level genes (APP, ApoE2, ApoE4, ABCA7, BIN1, Clu, CD33) for inflammatory markers (TLR-4, IL-8, TNF-α) by RT-qPCR in human glioblastoma (U87MG) astrocyte (1321N1) cell lines. The cytokines was further assessed ELISA assay. exposure U97MG 1321N1 cells resulted significant enhancement allele while reducing protective ApoE2. remarkably increased main genes, also pro-inflammatory cytokines. Furthermore, noticed substantial elevation mRNA transmembrane receptor TLR-4 following Our findings presented stimulate trigger neuroinflammation tissue. This, principle, leads recommendation that AD should perhaps test receive treatments upon positive detection.
منابع مشابه
Relationship of Social Risk Factors and Helicobacter pylori Infection with Pathological Characteristics of Gastric Carcinoma
Background: Cancer is the priority of the World Health Organization (WHO) and a serious challenge in death of human untimely. Assessment of social and physiological risk factors in gastric carcinoma patients can reveal the reasons of high prevalence gastric carcinoma in Sanandaj city. Methods: In a descriptive cross-sectional study, the variables of sex, age, education, occupation and active H...
متن کاملAssociation of Helicobacter Pylori Infection with Cardiometabolic Risk Factors among Iranian Adolescents: the CASPIAN III Study
Background: At least half the world’s population is colonized the stomach by Helicobacter pylori (H. pylori) which are a key constituent of the human microbiome. The aim of this study was to investigate the association of cardiometabolic risk factors with H. pylori infection in Iranian adolescents. Materials and Methods: The current study was conducted along with the third survey of a national ...
متن کاملAssociation between Helicobacter pylori Infection and Atherosclerotic Coronary Artery Disease
Background and Objectives: Cardiovascular disease is the most common cause of death in developed countries. In addition to traditional risk factors for cardiovascular disease, nowadays, accumulating evidence indicates that a variety of infections contribute to pathogenesis of atherosclerosis, (We investigated whether Helicobacter pylori infection is related to Prevalence of coronar...
متن کاملSerologic Detection of Helicobacter pylori Infection and the Required Cautions
Introduction: Helicobacter pylori, as an etiologic cause of peptic ulcers and gastric cancer, should be tested and treated. The true state of infection can only be detected by isolation of gastric biopsies through the invasive method of gastroscopy. However, there are several non-invasive methods for detection of infection, the most common of which is serology. Methods: Here we have evaluated t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Heliyon
سال: 2023
ISSN: ['2405-8440']
DOI: https://doi.org/10.1016/j.heliyon.2023.e19607