Helicobacter pylori: Future perspectives in therapy reflecting three decades of experience

Treatment of Helicobacter pylori: future therapeutic and prophylactic perspectives.

Helicobacter is one of the most widespread, chronic infections in the world and causes a serious disease with a significant mortality. The organism is difficult to eradicate using antibiotic therapy and to date no vaccine is available for use in humans. The most successful treatments comprise acid suppression in combination with two antibiotics and a series of seven day courses will reliably cu...

Therapy of Helicobacter pylori: Present Medley and Future Prospective

The increasing prevalence of antimicrobial resistance has warned clinicians to adopt new strategies for dealing with the H. pylori infection. The success of various therapeutic regimens has recently declined to unacceptable levels. To date, first line therapies (including concomitant therapy and hybrid therapy), second line therapies (including bismuth-containing quadruple therapy and levofloxa...

Helicobacter pylori — Current Therapy and Future Therapeutic Strategies

First-line therapy in Helicobacter pylori eradication therapy: experience of a surgical clinic.

OBJECTIVE Helicobacter pylori (HP) is the world's most common infectious agent. Despite conventional therapy consisting of proton pump inhibitor (PPI), amoxicillin (AMO) and clarithromycin (CLA), approximately half of the patients remain infected. We compared the PPI-based triple therapy with quadruple treatment (BPMT) including bismuth citrate (BS), PPI, metronidazole (MET) and tetracycline (T...

Three Decades of Antihypertensive Therapy

A h i s t o r i c a l r e p r e s e n t a t i o n o f t h e m a i n e v e n t s o f a t r u l y r e v o l u t i o n a r y p e r i o d of d r u g r e s e a r c h w h i c h l e d t o a r a t i o n a l m e d i c a l a p p r o a c h i n t h e t r e a t m e n t of h y p e r t e n s i o n i s t o s h e d l i g h t o n t h e c o n v e r s i o n of p h a r m a c o l o g i c a l s u b s t a n c e s i n ...