Helicobacter pylori causes delayed gastric emptying by decreasing interstitial cells of Cajal

Helicobacter pylori (HP) infection is one of the most frequent bacterial infections in humans and associated with pathogenesis gastric motility disorders such as delayed emptying (DGE). Although HP considered to delay emptying, there has been little research on underlying mechanism. Gastric involves interactions among gastrointestinal hormones, smooth muscle, enteric extrinsic autonomic nerves interstitial cells Cajal (ICCs), ICCs play an important role motility. Mutation or loss stem cell factor (SCF) expression known reduce number alter integrity ICC network, contributing dysmotility. The aim present study was investigate whether a reduction contributes DGE caused by HP. A mouse model established compared between HP?infected uninfected mice using bead method. In addition, counts SCF levels tissue were evaluated immunohistochemistry western blotting, respectively. results revealed that significantly slower, reduced protein level decreased mice. Therefore, it may be concluded decreasing tissue, thereby causing DGE.