Helicobacter pylori and gastric acid: an intimate and reciprocal relationship

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Helicobacter pylori and gastric acid: an intimate and reciprocal relationship

Helicobacter pylori (Hp) is the main cause of gastritis, peptic ulcer disease and gastric cancer. There are still unanswered questions related to the interaction between Hp and man, like what determines the susceptibility for the initial infection and the mechanisms for the carcinogenic effect. The initial infection seems to require a temporal gastric hypoacidity. For Hp to survive in the gastr...

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Helicobacter pylori is probably the commonest bacterial infection worldwide and is now accepted as the cause of gastritis, peptic ulcer, gastric carcinoma, and gastric lymphoma. In the last few years, besides the local gasteroduodenal tissue damage, an association between H.pylori and various extra-intestinal pathologies had been described. Recent studies have suggested that H.pylori infection ...

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Relationship between Helicobacter pylori gastritis, gastric cancer and gastric acid secretion.

Epidemiological evidence strongly indicates that Helicobacter pylori infection is an essential factor for the development of most non-cardia gastric cancer. Furthermore, the identification of an effective animal model and a plausible biological hypothesis provide further compelling evidence for its pathogenic role. Nevertheless, it will be some years before prospective studies in humans are abl...

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ژورنال

عنوان ژورنال: Therapeutic Advances in Gastroenterology

سال: 2016

ISSN: 1756-2848,1756-2848

DOI: 10.1177/1756283x16663395