منابع مشابه
Hedgehog signaling.
The Hedgehog (Hh) proteins belong to one of a small number of families of secreted signals that play a central role in the development of most metazoans. hh itself was originally identified as a mutation that causes a “segment polarity” phenotype in Drosophila—as were most of the core components of the Hh signal transduction pathway (Ingham et al. 2011). These components have been highly conser...
متن کاملParacrine Hedgehog signaling in cancer.
Ligand-dependent and ligand-independent activation of the Hedgehog (Hh) signaling pathway is involved in tumorigenesis. The importance of mutations in Hh pathway components leading to constitutive signaling has been well established in basal cell carcinoma and medulloblastoma. However, the role of ligand-driven Hh pathway activation in cancer remains to be established. Three recent articles sup...
متن کاملHedgehog signaling in pancreas development
Hedgehog proteins are secreted molecules that bind to their cell surface receptors to elicit concentration dependent responses essential for numerous tissue patterning and cell differentiation events during embryogenesis. However, during early stages of pancreas organogenesis, hedgehog signaling has been shown to inhibit tissue morphogenesis and cell differentiation. By contrast, recent cell cu...
متن کاملHedgehog Signaling in Endochondral Ossification
Hedgehog (Hh) signaling plays crucial roles in the patterning and morphogenesis of various organs within the bodies of vertebrates and insects. Endochondral ossification is one of the notable developmental events in which Hh signaling acts as a master regulator. Among three Hh proteins in mammals, Indian hedgehog (Ihh) is known to work as a major Hh input that induces biological impact of Hh si...
متن کاملShifting paradigms in Hedgehog signaling.
Hedgehog (Hh) signaling proteins regulate multiple developmental and adult homeostatic processes. A defining feature of Hh signaling is that relatively small changes in the concentration of Hh ligand elicit dramatically different cellular responses. As a result, the processing, release and trafficking of Hh ligands must be tightly regulated to ensure proper signaling. In addition, sensitive and...
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ژورنال
عنوان ژورنال: Critical Reviews™ in Eukaryotic Gene Expression
سال: 2010
ISSN: 1045-4403
DOI: 10.1615/critreveukargeneexpr.v20.i2.30