Hedgehog and Spitz

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Hedgehog and Spitz Making a Match between Photoreceptor Axons and Their Targets

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Angiomatoid Spitz Nevus.

Spitz nevus is a variant of melanocytic nevus which is histopathologically defined as large spindle and/or epithelioid cells. Angiomatoid Spitz nevus is a rare histologic variant of desmoplastic Spitz nevus characterized by prominent vasculature. We present a case of angiomatoid Spitz nevus, celluar type, that has not been reported before. We provide another example to show the remarkable diver...

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Spitz on growth control

S elf reliance is not enough. Some organs rely on the kindness of others to control their size, according to Correct organ size is measured in mass, not cell numbers— forcing or blocking cell division generally does not change an organ's overall dimensions. Parker found the same is true in the fl y embryonic P compartment, which forms part of the larval epidermis. Increases in P compartment cel...

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Spitz and Reed nevi: acquired or congenital?

Although conflicting with the concept of nevi being hamartomas, to date, Spitz and Reed nevi have been regarded as acquired melanocytic nevi, whereas many other types have already been accepted as being congenital. Here, the reader will find a survey on clinical, dermatoscopic and histopathologic clues suggesting a congenital origin of authentic Spitz nevi. Relevant differences in respect to Re...

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The Spectrum of Spitz Nevi

Main Outcome Measure: Frequency of dermoscopic patterns within the different histopathologic subtypes of Spitz nevi. Results: Overlapping clinical, dermoscopic, and histopathologic findings were observed among PSN, RN, and PSRN, thereby justifying their inclusion into the single PSRN diagnostic category. Asymmetry was the most frequent indicator of histopathologic ASN (79%; n=11); in only 4 cas...

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ژورنال

عنوان ژورنال: Cell

سال: 1998

ISSN: 0092-8674

DOI: 10.1016/s0092-8674(00)81627-x