منابع مشابه
Light and heavy chain deposition disease associated with CH1 deletion
Light and heavy chain deposition disease (LHCDD) is a rare complication of monoclonal gammopathy. In all documented cases, LHCDD is the association of deposits of a monoclonal light chain with a normal heavy chain, especially in the kidneys. We describe here a 78-year-old woman whose renal biopsy showed nodular glomerulosclerosis, initially diagnosed as diabetic nephropathy. Detailed kidney bio...
متن کاملRecurrent light and heavy chain deposition disease after renal transplantation.
Light and heavy chain deposition disease (LHCDD) is a rare entity with less than two dozen reported cases [1,2]. The term LHCDD was proposed in 1984 as a variant of light chain deposition disease (LCDD), to characterize a subset of patients in whom deposits contain both light and heavy chain antigenic determinants. We present a case of LHCDD in a renal graft and evidence that this process repre...
متن کاملHeavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment
Heavy-chain deposition disease (HCDD) is the least common of the monoclonal immunoglobulin deposition diseases with only 24 reported cases in English literature, including the present case. The rarity of this disease merits its documentation. We present a case of HCDD from our archival material, who presented with rapidly progressive renal failure and nephrotic syndrome and was found to have no...
متن کاملHigh dose chemotherapy in light chain or light and heavy chain deposition disease.
BACKGROUND Conventional chemotherapy for myeloma yield unsatisfactory results in light and/or heavy chain deposition disease [(H)CDD] Because of the well-established dose-response effect of high dose melphalan in multiple myeloma, aiming to dramatically reduce the pathogenic monoclonal immunoglobulin (MIg) level, high dose therapy is a tempting alternative approach. METHODS We treated 11 youn...
متن کاملGamma heavy chain disease simulating alpha chain disease.
A young Turkish girl presented with all the clinicopathological features of a digestive form of alpha chain disease. A gamma heavy chain disease protein, however, was found in her serum and also in the cells invading the intestinal mucosa and mesenteric lymph nodes.
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 1993
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejm199311043291905