Heat Stable Protein with Anticoagulant and Smooth Muscle Contractile Actions Isolated from Habu (Trimeresurus flavoviridis) Venom

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Heat stable protein with anticoagulant and smooth muscle contractile actions isolated from Habu (Trimeresurus flavoviridis) venom.

The biological activity of a Habu (Trimeresurus flavoiridis) venom fraction with drug-metabolizing enzyme inhibitory action was studied. The venom fraction, which was isolated through Sephadex G-100 gel filtration and cation exchange chromatography on Amberlite CG50, caused an increase of vascular permeability and hemorrhage, but these actions were lost after heating at 70 degrees C for 5 min. ...

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Biological and Pathological Studies of Rosmarinic Acid as an Inhibitor of Hemorrhagic Trimeresurus flavoviridis (habu) Venom

In our previous report, rosmarinic acid (RA) was revealed to be an antidote active compound in Argusia argentea (family: Boraginaceae). The plant is locally used in Okinawa in Japan as an antidote for poisoning from snake venom, Trimeresurus flavoviridis (habu). This article presents mechanistic evidence of RA's neutralization of the hemorrhagic effects of snake venom. Anti-hemorrhagic activity...

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Immunogenicity of a toxoid of Habu (Trimeresurus flavoviridis) venom in various animal species including man.

A mixed toxoid consisting of HR1 and HR2 toxoids derived from Habu (Trimeresurus flavoviridis) venom was examined for immunogenicity in guinea pigs, rabbits, monkeys and human beings. The toxoid produced both anti-HR1 and anti-HR2 in various animals. The immunogenicity of the toxoid was superior to a crude toxoid in both guinea pigs and monkeys. Immunized monkeys showing circulating antitoxin p...

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Enhancement of hepatic microsomal aniline hydroxylation by Habu snake (Trimeresurus flavoviridis) venom fractions.

Enhancement of aniline hydroxylation by Habu snake venom was studied in vitro. The fraction which was isolated from Habu venom through column chromatography caused the enhancement of aniline hydroxylation of hepatic microsomes obtained from untreated rats. This fraction was heat stable and free from phospholipase activity. Enhancement of aniline hydroxylation was not clear in crude Habu venom o...

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Characteristics of cardiovascular effects of the venom of habu (Trimeresurus flavoviridis) in rats.

Characteristics of the cardiovascular effects of habu venom were studied in vivo and in vitro in rats. Aortic pressure (AoP), heart rate (HR) and renal cortical blood flow (RCBF) assessed by a laser-Doppler flowmeter were measured in anesthetized rats. Administration of habu venom (0.2-1.6 mg/kg, i.v.) dose-dependently produced a fall in AoP without a marked change in HR. RCBF decreased signifi...

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ژورنال

عنوان ژورنال: Japanese Journal of Pharmacology

سال: 1985

ISSN: 0021-5198

DOI: 10.1254/jjp.39.437