Heart Failure With Midrange Ejection Fraction: Prior Left Ventricular Ejection Fraction and Prognosis
نویسندگان
چکیده
Aims: Evidence-based guidelines for heart failure management depend mainly on current left ventricular ejection fraction (LVEF). However, fewer studies have examined the impact of prior LVEF. Patients may enter with midrange (HFmrEF) category when preserved (HFpEF) deteriorates or reduced (HFrEF) improves. In this study, we association between change in LVEF and adverse outcomes. Methods: HFmrEF patients at least two more echocardiograms 3 months apart First Affiliated Hospital Dalian Medical University September 1, 2015 November 30, 2019 were identified. According to LVEF, subjects divided into improved group (prior < 40%), stable 40 50%), deteriorated ? 50%). The primary outcomes cardiovascular death, all-cause mortality, hospitalization worsening failure, composite event mortality hospitalization. Results: A total 1,168 (67.04% male, mean age 63.60 ± 12.18 years) included. percentages improved, stable, 310 (26.54%), 334 (28.60%), 524 (44.86%), respectively. After a period follow-up, 208 (17.81%) died 500 met endpoint. rates 35 (11.29%), 55 (16.47%), 118 (22.52%), outcome was 102 (32.90%), 145 (43.41%), 253 (48.28%) groups, Cox regression analysis showed that deterioration had higher risk death (HR: 1.707, 95% CI: 1.064–2.739, P = 0.027), (HR 1.948, CI 1.335–2.840, 0.001), 1.379, 1.096–1.736, 0.006) compared improvement group. still remained significant after fully adjusted both 1.899, 1.247–2.893, 0.003) 1.324, 1.020–1.718, 0.035). Conclusion: are heterogeneous three different subsets identified, each Strategies managing should include previously measured allow stratification based direction changes better optimize treatment.
منابع مشابه
Changes in Left Ventricular Ejection Fraction Predict Survival and Hospitalization in Heart Failure With Reduced Ejection Fraction.
BACKGROUND Left ventricular remodeling, as commonly measured by left ventricular ejection fraction (LVEF), is associated with clinical outcomes. Although change in LVEF over time should reflect response to therapy and clinical course, serial measurement of LVEF is inconsistently performed in observational settings, and the incremental prognostic value of change in LVEF has not been well charact...
متن کاملassociation between androgenic hormone levels and left ventricular ejection fraction
background : androgens have been shown to have diverse effects on the cardiovascular system. the aim of this study was to compare androgenic hormone levels in patients with different left ventricular ejection fractions (ef). methods : the study population consisted of 515 consecutive men who were referred for angiographic studies and whose results of echocardiography and coronary angiography we...
متن کاملHeart Failure With Preserved Ejection Fraction
The Journal of the American Osteopathic Association July 2015 | Vol 115 | No. 7 432 From Henry Ford Wyandotte Downriver Cardiology in Brownstown, Michigan (Dr Rogers); West Suburban Medical Center in Oak Park, Illinois (Dr Gundala); Oakwood Southshore Medical Center in Trenton, Michigan (Dr Ramos); and Elmhurst Memorial Hospital in Illinois (Dr Serajian). Drs Gundala and Ramos are in their thir...
متن کاملHeart Failure With Preserved Ejection Fraction
Symptomatic heart failure, despite preserved left ventricular (LV) ejection fraction, is a well-recognized phenomenon. This manifestation of diastolic dysfunction is associated with increased morbidity and mortality and can be attributed to a variety of pathogeneses, including diabetes mellitus, hypertension, infiltrative processes, and obesity. Unlike in systolic heart failure, where LV ejecti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Cardiovascular Medicine
سال: 2021
ISSN: ['2297-055X']
DOI: https://doi.org/10.3389/fcvm.2021.697221