Heart failure: a hemodynamic disorder complicated by maladaptive proliferative responses
نویسندگان
چکیده
منابع مشابه
Is erythropoietin behind maladaptive anemic heart failure?
HEART FAILURE (HF) is a major public health problem worldwide. HF is a syndrome arising from multiple causes that will affect one in five adults in their lifetime. Despite the progress that has been made in the treatment of chronic HF, the overall morbidity and mortality remain high (8). Therefore, it is imperative that there is a continued push to more fully understand the molecular mechanisms...
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BACKGROUND Reactive oxygen species (ROS) play an important role in the maintenance of cardiovascular homeostasis. The present study sought to determine whether nuclear factor erythroid-2 related factor 2 (Nrf2), a master gene of the endogenous antioxidant defense system, is a critical regulator of the cardiac hypertrophic response to pathological stress. METHODS AND RESULTS Cardiac hypertroph...
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Hemodynamic monitoring has moved in the last few years from being the holy grail of evaluating patients with acute heart failure to being all but extinct. Recent studies have not demonstrated any sustained benefits from right heart catheterization, and some studies have even suggested harm due to adverse events related to this invasive procedure. It is possible that this lack of efficacy is rel...
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Desai/Fig.2: Growing Burden of HF It is now well established that heart failure (HF) is a growing problem for the American healthcare system and even worldwide. The American Heart Association projects that the total number of prevalent cases of patients with HF will increase from roughly 5 million in the current era to nearly 8 million by 2030 – an increase of about 46%.[1] That means that in 2...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2003
ISSN: 1582-1838,1582-4934
DOI: 10.1111/j.1582-4934.2003.tb00197.x