Hear, Hear for Notch: Control of Cell Fates in the Inner Ear by Notch Signaling
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چکیده
منابع مشابه
Hear, Hear for the Zebrafish
Our senses of hearing and balance rely on the function of specialized receptor neurons called "hair cells." In this issue of Neuron, Grant et al. report a series of elegant zebrafish experiments that reveal a previously unappreciated role for glia in the regulation of hair cell proliferation and differentiation. This work is a beautiful example of how zebrafish are particularly useful model sys...
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Asymmetric cell divisions play a key role in establishing neuronal diversity in the mammalian and Drosophila CNS, but the mechanisms involved are mostly unknown. The Drosophila MP2 precursor divides asymmetrically to generate the dMP2/vMP2 interneurons. Delta-Notch signaling is required to specify vMP2 fate, whereas the localized determinant Numb is segregated into dMP2 and is required to speci...
متن کاملNotch signaling alters sensory or neuronal cell fate specification of inner ear stem cells.
Multipotent progenitor cells in the otic placode give rise to the specialized cell types of the inner ear, including neurons, supporting cells, and hair cells. The mechanisms governing acquisition of specific fates by the cells that form the cochleovestibular organs remain poorly characterized. Here we show that whereas blocking Notch signaling with a γ-secretase inhibitor increased the convers...
متن کاملNotch signaling in the development of the inner ear: lessons from Drosophila.
The sensory patches in the ear of a vertebrate can be compared with the mechanosensory bristles of a fly. This comparison has led to the discovery that lateral inhibition mediated by the Notch cell-cell signaling pathway, first characterized in Drosophila and crucial for bristle development, also has a key role in controlling the pattern of sensory hair cells and supporting cells in the ear. We...
متن کاملCell proliferation control by Notch signaling in Drosophila development.
The Notch receptor mediates cell interactions controlling the developmental fate of a broad spectrum of undifferentiated cells. By modulating Notch signaling in specific precursor cells during Drosophila imaginal disc development, we demonstrate that Notch activity can influence cell proliferation. The activation of the Notch receptor in the wing disc induces the expression of the wing margin p...
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ژورنال
عنوان ژورنال: Biomolecules
سال: 2020
ISSN: 2218-273X
DOI: 10.3390/biom10030370