Head-to-head randomized trials are mostly industry sponsored and almost always favor the industry sponsor
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چکیده
منابع مشابه
Characteristics of NIH- and industry-sponsored head and neck cancer clinical trials.
OBJECTIVES/HYPOTHESIS Compare U.S. clinical trials sponsored by the National Institutes of Health (NIH) and industry, especially with regard to trial design, interventions studied, and results reporting rates. STUDY DESIGN U.S. head and neck cancer clinical trials. METHODS We used information from ClinicalTrials.gov to compare NIH- and industry-sponsored head and neck cancer clinical trials...
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BACKGROUND Mapping the international landscape of clinical trials may inform global health research governance, but no large-scale data are available. Industry or non-industry sponsorship may have a major influence in this mapping. We aimed to map the global landscape of industry- and non-industry-sponsored clinical trials and its evolution over time. METHODS We analyzed clinical trials initi...
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OBJECTIVE To assess if commercially sponsored trials are associated with higher success rates than publicly-sponsored trials. STUDY DESIGN AND SETTINGS We undertook a systematic review of all consecutive, published and unpublished phase III cancer randomized controlled trials (RCTs) conducted by GlaxoSmithKline (GSK) and the NCIC Clinical Trials Group (CTG). We included all phase III cancer R...
متن کاملRemoving the cloud from industry-sponsored, multicentered clinical trials.
It has been said that laws are imposed on 99% of the population to help prevent the improprieties of the remaining 1%. Although we like to think that the scientific process is exacting, rigorous, and honorable, unfortunately our community also needs oversight. Over the past 4 years as Editor-in-Chief of Blood, I have witnessed an alarming increase in the incidence of scientific misconduct, incl...
متن کاملDesign and reporting modifications in industry-sponsored comparative psychopharmacology trials.
This review of recently published pharmaceutical industry-sponsored comparative psychotropic drug trials aims to classify apparent design and reporting modifications that favor the sponsor's product. The modifications have been grouped into 13 discrete categories, and representative examples of each are presented. Strong circumstantial evidence suggests that marketing goals led to these adjustm...
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ژورنال
عنوان ژورنال: Journal of Clinical Epidemiology
سال: 2015
ISSN: 0895-4356
DOI: 10.1016/j.jclinepi.2014.12.016