HDL, lipid peroxidation, and atherosclerosis

1 HDL , Lipid Peroxidation , and Atherosclerosis

Lipid peroxidation and platelet activation in murine atherosclerosis.

BACKGROUND Lipid peroxidation and platelet activation are thought to be important contributors to the pathogenesis of atherosclerosis. The relevance of their interaction in vivo, however, is unknown. METHODS AND RESULTS LDL receptor-deficient (LDLR(-/-)) mice on a high-fat diet developed extensive atherosclerosis and had increased urinary levels of 8,12-iso-isoprostane (iP) F(2alpha)-VI and 2...

HDL, Atherosclerosis, and Emerging Therapies

This review aims to provide an overview on the properties of high-density lipoproteins (HDLs) and their cardioprotective effects. Emergent HDL therapies will be presented in the context of the current understanding of HDL function, metabolism, and protective antiatherosclerotic properties. The epidemiological association between levels of HDL-C or its major apolipoprotein (apoA-I) is strong, gr...

Lipid Peroxidation

Södergren, E. 2000. Lipid peroxidation in vivo. Evaluation and application of methods for measurement. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 949. 78 pp. Uppsala. ISBN 91-554-4791-0. Lipid peroxidation is thought to be an important factor in the pathophysiology of a number of diseases and in the process of ageing, but its me...

Lipid peroxidation and nutrition.

Levels of conjugated dienes of fatty acids (first peroxidation product) in relation to their substrates and promotors (triacylglycerols, homocysteine, iron) as well as to their inhibitors (essential antioxidative vitamins) were assessed in a vegetarian group (n=24) and compared with subjects on a mixed diet (traditional nutrition, n=24). Positive significant linear correlation between conjugate...