منابع مشابه
Control of GVHD: it's in our DNA!
Selective depletion of the alloreactive T cells causing graft-versus-host disease (GVHD) without loss of the graft-versus-leukemia (GVL) effect is the holy grail of hematopoietic cell transplantation (HCT). In this issue of Blood, He et al demonstrate that inhibition of histone methylation leads to selective apoptosis of the alloreactive effector cells. Moreover, they demonstrate that this inhi...
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NIQUE AMONG INFECTIOUS AGENTS, retroviruses provide the opportunity for studying their own evolution, evolution of the host-virus relationship, and evolution of the host. This utility stems from the property that retroviruses must, as a normal and essential part of every cycle of replication, cause their genetic information, in the form of a DNA molecule called the provirus, to be joined with, ...
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Variability in the human genome has far exceeded expectations. In the course of the past three years, we have learned that much of our naturally occurring genetic variation consists of large-scale differences in genome structure, including copy-number variants (CNVs) and balanced rearrangements such as inversions. Recent studies have begun to reveal that structural variants are an important con...
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Epigenetics affects health, appearance and behavior and propagates mammalian phenotypes across generations. Nutrients, drugs and behavior can all direct changes in epigenetics. In at least some cases, these directed changes are propagated across generations. This range of influences on epigenetics suggests that epigenetics is highly interactive with the environment. Changes in the environment m...
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Introduction: Long term complications of hepatitis C virus (HCV) infection include fibrosis, cirrhosis, and hepatocellular carcinoma and although the disease is treatable with the newly introduced direct acting antivirals, but factors such as drug resistance, viral genotype and adverse effects can limit the effectiveness of therapy. Therefore, development of effective, safe and affordable proph...
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ژورنال
عنوان ژورنال: Self/Nonself
سال: 2011
ISSN: 1938-2030,1938-2049
DOI: 10.4161/self.2.2.15795