HCV-associated cryoglobulinemia vasculitis: are its days numbered?

Cryoglobulinemia Vasculitis.

Cryoglobulinemic vasculitis (CryoVas) is a small-vessel vasculitis involving mainly the skin, the joints, the peripheral nervous system, and the kidneys. Type I CryoVas is single monoclonal immunoglobulins related to an underlying B-cell lymphoproliferative disorder. Type II and III cryoglobulins, often referred to as mixed cryoglobulinemia, consist of polyclonal immunoglobulin (Ig)G with or wi...

Peripheral Ulcerative Keratitis Associated with HCV-Related Cryoglobulinemia

PURPOSE To describe a case of peripheral ulcerative keratitis associated with type II cryoglobulinemia in the context of Hepatitis C infection. METHODS Case report and literature review. RESULTS A 36-year-old male patient presented to our emergency department with unilateral moderate pain in his right eye, associated with redness and photophobia. Medical background elicited a history of Hep...

INCREASED SERUM LEVELS OF THE CHEMOKINE CXCL13 AND UP-REGULATION OF ITS GENE EXPRESSION ARE DISTINCTIVE FEATURES OF HCV-RELATED CRYOGLOBULINEMIA AND CORRELATE WITH ACTIVE CUTANEOUS VASCULITIS Short Title: CXCL13 in HCV-related cryoglobulinemic vasculitis

Chemokine CXCL13, also known as BCA-1 (B-cell attracting chemokine-1) or BLC (B-lymphocyte chemoattractant), is a major regulator of B cell trafficking. Hepatitis C virus (HCV) infection may be associated with B cell dysfunction and lymphoproliferative disorders, including mixed cryoglobulinemia (MC). This study evaluates circulating levels of CXCL13 protein and specific mRNA expression in chro...

The Spectrum of Type I Cryoglobulinemia Vasculitis

Type I cryoglobulinemia vasculitis (CryoVas) is considered a life-threatening condition; however, data on the characteristics and outcome are scarce. To analyze the presentation, prognosis, and efficacy and safety of treatments of type I CryoVas, we conducted a French nationwide survey that included 64 patients with type I CryoVas between January 1995 and July 2010: 28 patients with monoclonal ...

HCV, Mixed Cryoglobulinemia and Malignant Lymphoproliferation