HBV cccDNA: The Stumbling Block for Treatment of HBV Infection
نویسندگان
چکیده
منابع مشابه
Minicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and developing cccDNA-targeting drugs
Chronic Hepatitis B Virus (HBV) infection is generally not curable with current anti-viral drugs. Virus rebounds after stopping treatment from the stable HBV covalently-closed-circular DNA (cccDNA). The development of drugs that directly target cccDNA is hampered by the lack of robust HBV cccDNA models. We report here a novel HBV cccDNA technology that will meet the need. We engineered a minici...
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ژورنال
عنوان ژورنال: Journal of Clinical and Translational Hepatology
سال: 2019
ISSN: 2225-0719,2310-8819
DOI: 10.14218/jcth.2019.00047