Harnessing DNA-induced immune responses for improving cancer vaccines
نویسندگان
چکیده
منابع مشابه
Harnessing DNA-induced immune responses for improving cancer vaccines.
DNA vaccines have emerged as an attractive strategy to promote protective cellular and humoral immunity against the encoded antigen. DNA vaccines are easy to generate, inexpensive to produce and purify at large-scale, highly stable and safe. In addition, plasmids used for DNA vaccines act as powerful "danger signals" by stimulating several DNA-sensing innate immune receptors that promote the in...
متن کاملStrategies for improving responses to DNA vaccines.
A DNA vaccine consists of a plasmid that allows expression of an antigen encoded by an inserted gene or cDNA in mammalian cells as directed by a strong promoter element, usually of viral origin (i.e., human cytomegalovirus, rous sarcoma virus). The first report that intramuscular (i.m.) injection of plasmid DNA could be used as a mode for vaccination sparked worldwide interest (1). It has also ...
متن کاملth۱ platform immune responses against leishmania major induced by thiol-specific antioxidant-based dna vaccines
background: the thiol-specific antioxidant (tsa) is an antigen of leishmania major which is believed to be the most promising molecule as a vaccine candidate against leishmaniasis. objectives: in this study, we investigated the protective efficacy of tsa-based dna vaccine against l. major infection. materials and methods: recombinant plasmid construction tsa (pctsa) was prepared and transfected...
متن کاملHarnessing the Immune System to Fight Cancer: The Promise of Genetic Cancer Vaccines
In spite of significant progress in recent years towards the development of new targeted therapies Cancer is still a largely unmet medical need and the leading cause of death in industrialized countries (Globocan Project, 2008). Cancer is continuously increasing and is associated with a variety of factors, including genetic predisposition, infectious agents, exposure to mutagens, as well as lif...
متن کاملHarnessing the immune response for cancer detection.
The development of cancer is a multistep process. The most effective means for eradicating cancer is through detection and eradication of precursor lesions, as is done with removal of polyps to prevent colon cancer. For most cancers, we are challenged by lack of effective means to detect precursor lesions as well as cancerous lesions at an early stage. A strategy yet to be fully exploited stems...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Human Vaccines & Immunotherapeutics
سال: 2012
ISSN: 2164-5515,2164-554X
DOI: 10.4161/hv.22345