Harnessing alloreactivity to achieve anti-leukemic responses
نویسندگان
چکیده
منابع مشابه
Cellular Immunotherapy: Using Alloreactivity to Induce Anti-Leukemic Responses without Prolonged Persistence of Donor Cells
A goal of cancer immunologists is to harness cellular immune responses to achieve anti-cancer responses. One of the strongest activating stimuli for the immune system is the encounter with cells expressing allogeneic HLA molecules. While alloreactive responses can negatively impact of the outcome of hematopoietic stem cell transplant because of graft-versus-host disease (GVHD), these same respo...
متن کاملHarnessing Oncolytic Virus-Mediated Anti-Tumor Immunity
Oncolytic viruses (OVs) selectively infect, replicate in, and kill tumor cells. For a long time, the therapeutic efficacy of OVs was thought to depend mainly on this mechanism of direct viral oncolysis. Nowadays, however, the post-oncolytic anti-tumor activity induced by the OV therapy is considered a key factor for an efficient therapeutic activity. The research topic addresses these issues an...
متن کاملHarnessing the anti-inflammatory potential of palmitoylethanolamide.
Palmitoylethanolamide (PEA) is a peroxisome proliferator-activated receptor alpha (PPAR-α) ligand that exerts anti-inflammatory, analgesic and neuroprotective actions. PEA is synthetized from phospholipids through the sequential actions of N-acyltransferase and N-acylphosphatidylethanolamine-preferring phospholipase D (NAPE-PLD), and its actions are terminated by its hydrolysis by two enzymes, ...
متن کاملThe anti-leukemic action of combinations of certain known anti-leukemic agents.
The present study of the anti-leukemic action of combinations of certain rather diverse agents known to prolong survival time of mice with trans planted leukemia was prompted by the observa tion of an apparent anti-leukemic synergism be tween urethan and methyl-bis(@-chloroethyl)a mine (G). Urethan (3, 4, 5, 11), methyl-bis(@-chloroethyl) amine (HN@) (3, 4, 9), benzene (8, 6), potassium arsenit...
متن کاملLow-dose salinomycin induces anti-leukemic responses in AML and MLL
Development of anti-cancer drugs towards clinical application is costly and inefficient. Large screens of drugs, efficacious for non-cancer disease, are currently being used to identify candidates for repurposing based on their anti-cancer properties. Here, we show that low-dose salinomycin, a coccidiostat ionophore previously identified in a breast cancer screen, has anti-leukemic efficacy. AM...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Leukemia Supplements
سال: 2014
ISSN: 2044-5210,2044-5229
DOI: 10.1038/leusup.2014.6