Hard man to surprise

p53 continues to surprise

As one of the most intensively studied transcription factors, it is unsurprising that p53 is involved in many biological processes, including cell cycle arrest, DNA repair, senescence and apoptosis.1 its activities are mainly regulated by posttranslational modifications and interactions with other cellular components. Over the past few years, p53 has also been linked to redox homeostasis, the b...

Surprise, Surprise from Neoclassical Economics to E-life2

We build and describe an agent-based model: the Surprise Game. The game comprises a “world” of 30 fi rms, each of which has to survive (and, if possible, prosper) in its environment, which is nothing more than the other 29 fi rms. Each fi rm has to latch onto one or other of the four strategies that are predicted by the theory of plural rationality but has to relinquish that strategy and latch ...

Explanation to Avert Surprise

Most explanation schemes are reactive and informational: explanations are provided in response to specific user queries and focus on making the system’s reasoning more transparent. In mixed autonomy settings that involve teams of humans and autonomous agents, proactive explanation that anticipates and preempts potential surprises can be particularly valuable. By providing timely, succinct, and ...

The 'axe man' departs, offering hard-won lessons.

‘My late husband Mr Anua was a hard-working man’

I was approximately 12–13 years old when Dr Carleton Gajdusek came into the Purosa Valley to do research on kuru. My late husband Mr Anua was a hard-working man. He helped Carleton and Michael Alpers in their fieldwork. Sometimes when he was asked to go to other villages to report on kuru patients, I had to accompany him and we both went out. I have seen more of the villages to the south and we...