Haplotypes responsible for early embryonic lethality detected in Nordic Holsteins
نویسندگان
چکیده
منابع مشابه
Identification of Quantitative Trait Loci responsible for embryonic lethality in mice assessed by ultrasonography.
Recurrent Spontaneous Abortion (RSA) is a frequent pathology affecting 1 to 5% of couples. In approximately 50 % of cases, the aetiology is unknown suggesting a subtle interaction between genetic and environmental factors. Previous attempts to describe genetic factors using the candidate gene approach have been relatively unsuccessful due to the physiological, cellular and genetic complexity of...
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متن کاملADAR1 isoform involvement in embryonic lethality.
Letters to the editor recently published in PNAS (1, 2) challenged and defended a claim made on a recent article (3). Matthaei et al. (1) questioned whether the animal model used by Ward et al. (3) was adequate to support their claim that the P150 isoform of the RNA editing enzyme adenosine deaminase 1 (ADAR1) is required for embryogenesis. We believe the question remains open and present data ...
متن کاملIs the p150 isoform of the RNA editing enzyme Adenosine Deaminase 1 really responsible for embryonic lethality?
We read with interest the manuscript by Ward et al. (1) in PNAS in which selective disruption of the p150 isoform, but not the p110 isoform, of the RNA editing enzyme Adenosine Deaminase 1 (ADAR1) was reported to cause early embryonic lethality. ADAR1 exists in two molecular weight isoforms: a long protein of 150 kDa (p150), which is expressed from an interferoninducible promoter using a transl...
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ژورنال
عنوان ژورنال: Journal of Dairy Science
سال: 2019
ISSN: 0022-0302
DOI: 10.3168/jds.2019-16651