Haplotypes frequencies of CYP2B6 in Malaysia
نویسندگان
چکیده
منابع مشابه
HLA Haplotypes and Genotypes Frequencies in Brazilian Chronic Periodontitis Patients
Human leukocyte antigens (HLA) have a pivotal role in immune response and may be involved in antigen recognition of periodontal pathogens. However, the associations of HLA with chronic periodontitis (CP) have not been previously studied in the Brazilian population. In an attempt to clarify the issue of genetic predisposition to CP, we examined the distribution of HLA alleles, genotypes, and hap...
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The gene for the ß 3 (GPIIIa) subunit of the integrin α IIb ß 3 (GPIIb-IIIa) present on the platelet membrane contains the platelet antigen alleles (PlA) in a homozygous form (Pl/) or the heterozygous or polymorphic form (Pl/) in humans. This GPIIIa subunit serves as a receptor for adhesive proteins (viz. fi brinogen and von Willebrand factor) and is critical for platelet aggregation. The struc...
متن کاملHaplotype structure and allele frequencies of CYP2B6 in a Korean population.
Cytochrome P450 2B6 (CYP2B6) metabolizes a number of therapeutic drugs and its metabolic activity varies markedly in human liver. Although genetic polymorphisms of CYP2B6 have been reported in noncoding and coding regions, little information is available regarding single nucleotide polymorphisms (SNPs) and their haplotypes in noncoding regions in Asians. Fourteen previously reported SNPs were d...
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Objective(s):Organic anion transporter polypeptide 1B1 (OATP1B1) encoded by solute carrier organic transporter 1B1 (SLCO1B1) gene; a transporter involved in the uptake of drugs and endogenous compounds is present in hepatocyte sinusoidal membrane. Aim of this study was to investigate the frequencies of functionally significant SNPs (388A>G and 521T>C) and their haplotypes in 6 ethnic groups of ...
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ژورنال
عنوان ژورنال: Journal of Postgraduate Medicine
سال: 2012
ISSN: 0022-3859
DOI: 10.4103/0022-3859.105439