Haplotype analysis of the apolipoprotein gene cluster on human chromosome 11
نویسندگان
چکیده
منابع مشابه
Human apolipoprotein A-I--C-III gene complex is located on chromosome 11.
The genes for two of the apolipoproteins, apo A-I and apo C-III, previously shown to be within 3kb in the genome, were localized to human chromosome 11 by Southern blot analysis of DNA from human-rodent somatic cell hybrids. These two genes were shown to exhibit polymorphisms associated with dyslipoproteinemia and premature atherosclerosis, and it will now be possible to examine the relationshi...
متن کاملHuman Apolipoprotein A-l-C-lll Gene Complex is Located on Chromosome 11
The genes for two of the apolipoproteins, apo A-l and apo C-lll, previously shown to be within 3kb In the genome, were localized to human chromosome 11 by Southern blot analysis of DNA from human-rodent somatic cell hybrids. These two genes were shown to exhibit polymorphisms associated with dysllpoproteinemia and premature atherosclerosis, and It will now be possible to examine the relationshi...
متن کاملLocalization of the structural gene for human apolipoprotein A-I on the long arm of human chromosome 11.
Apolipoprotein A-I (apo A-I), the major apolipoprotein in human high density lipoproteins, is involved in the disease atherosclerosis. Cloned apo A-I cDNA (pA1-3) was used as a probe in chromosome mapping studies to detect the human apo A-I structural gene sequence in human-Chinese hamster cell hybrids. Southern blot analysis of 13 hybrids localized the gene to human chromosome 11. Confirmation...
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The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11.
The DDK syndrome is an early embryonic lethal phenotype observed in crosses between females of the DDK inbred mouse strain and many non-DDK males. Lethality results from an incompatibility between a maternal DDK factor and a non-DDK paternal gene, both of which have been mapped to the Ovum mutant (Om) locus on mouse chromosome 11. Here we define a 465-kb candidate interval for the paternal gene...
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ژورنال
عنوان ژورنال: Genomics
سال: 2004
ISSN: 0888-7543
DOI: 10.1016/j.ygeno.2003.11.016