Haplotype 4 of the multiple sclerosis-associated interleukin-7 receptor alpha gene influences the frequency of recent thymic emigrants
نویسندگان
چکیده
منابع مشابه
Association study of four polymorphisms in the interleukin-7 receptor alpha gene with multiple sclerosis in Eastern Iran
Objective(s): Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) with unknown etiology. Various genetics and environmental factors contribute to the pathogenesis of the disease. The interleukin-7 receptor alpha chain (IL-7Ra) was identified as the first non-major histocompatibility complex (non-MHC) MS susceptibility locus. In this study we are tr...
متن کاملassociation study of four polymorphisms in the interleukin-7 receptor alpha gene with multiple sclerosis in eastern iran
objective(s): multiple sclerosis (ms) is an autoimmune demyelinating disease of the central nervous system (cns) with unknown etiology. various genetics and environmental factors contribute to the pathogenesis of the disease. the interleukin-7 receptor alpha chain (il-7ra) was identified as the first non-major histocompatibility complex (non-mhc) ms susceptibility locus. in this study we are tr...
متن کاملVariation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis.
Multiple sclerosis is a chronic, often disabling, disease of the central nervous system affecting more than 1 in 1,000 people in most western countries. The inflammatory lesions typical of multiple sclerosis show autoimmune features and depend partly on genetic factors. Of these genetic factors, only the HLA gene complex has been repeatedly confirmed to be associated with multiple sclerosis, de...
متن کاملassociation of interleukin 7 receptor gene polymorphism rs6897932 with multiple sclerosis patients in khuzestan.
background: multiple sclerosis (ms) is a chronic inflammatory demyelinating and neurodegenerative disease of central nervous system with unknown causes. etiology of ms involves both genetic and environment factors. the interleukin 7 receptor (il7r) gene is a promising candidate for ms, because its involvement in the autoimmunity, regulation of the t-cell homeostasis...
متن کاملnew semigroup compactifications via the enveloping semigroups of associated flows
this thesis deals with the construction of some function algebras whose corresponding semigroup compactification are universal with respect to some properies of their enveloping semigroups. the special properties are of beigan a left zero, a left simple, a group, an inflation of the right zero, and an inflation of the rectangular band.
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2010
ISSN: 1466-4879,1476-5470
DOI: 10.1038/gene.2009.106