HAMSTER COAGULATION AND SERUM PROTEINS IN RAT RECIPIENTS OF HAMSTER XENOGRAFTS

Hamster coagulation and serum proteins in rat recipients of hamster xenografts.

After hepatic transplantation, liver allografts continue to produce donor-phenotype proteins and other synthetic products, allowing this operation to be used to correct numerous liver-based inborn errors of metabolism (1) . Because the same retention of donor specificity is expected after successful hepatic xenotransplantation, the consequence of successfully engrafting a liver xenograft could ...

Pretreatment of recipients (nude rat) with donor antigens leads to prolonged survival of hamster heart xenografts.

THE INITIAL barrier to successful organ xenotrans1. plantation in discordant species is hyperacute rejection (HAR) mediated by either natural (preformed) or induced antibodies. 1•2 Hamster cardiac xenografts are normally rejected by this mechanism within 3 days when transplanted into naive LEW or athymic (nude) rats,3 which in the latter is supposedly caused by a T-cell independent process. Thi...

Distribution of the serum proteins of Syrian hamster as revealed by Starch gel electrophoresis

Cytokine messenger RNA profiles in hamster-to-rat liver xenografts.

XENOGENEIC transplant rejection is thought to be mediated primarily by a humoral mechanism. Discordant xenografts are rejected hyperacutely by preformed natural antibodies recognizing genetically disparate donor cells. Concordant xenografts are also destroyed by antibodies; however, this rejection process takes place over a longer span of time, during which T-helper cells playa crucial role in ...

The Coronary Microcirculation in Hamster-to-Rat Cardiac Xenografts.

BACKGROUND The aim of this study was to establish a new experimental model to directly analyse the coronary microcirculation in cardiac xenografts. METHODS Intravital fluorescence microscopy (IVM) of the subepicardial microcirculation in heterotopically transplanted hamster-to-rat cardiac xenografts was performed at 30 and 90 min of reperfusion. We quantitatively assessed the microcirculatory...