HAMLET Kills Tumor Cells by Apoptosis: Structure, Cellular Mechanisms, and Therapy
نویسندگان
چکیده
منابع مشابه
Survival Xenografts by an Apoptosis-Like Mechanism and Prolongs (HAMLET) Kills Human Glioblastoma Cells in Brain -Lactalbumin Made Lethal to Tumor Cells
Malignant brain tumors present a major therapeutic challenge because no selective or efficient treatment is available. Here, we demonstrate that intratumoral administration of human -lactalbumin made lethal to tumor cells (HAMLET) prolongs survival in a human glioblastoma (GBM) xenograft model, by selective induction of tumor cell apoptosis. HAMLET is a protein-lipid complex that is formed from...
متن کاملHuman alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival.
Malignant brain tumors present a major therapeutic challenge because no selective or efficient treatment is available. Here, we demonstrate that intratumoral administration of human alpha-lactalbumin made lethal to tumor cells (HAMLET) prolongs survival in a human glioblastoma (GBM) xenograft model, by selective induction of tumor cell apoptosis. HAMLET is a protein-lipid complex that is formed...
متن کاملSelectively Kills Tumor Cells
nloaded 1 kinase activates multiple transcription factors and regulates the level of reactive oxygen species We have previously reported that ablation of TAK1 in keratinocytes causes hypersensitivity to ROSd cell apoptosis. It is known that some tumor cells produce ROS at higher levels compared with normal e used inducible epidermal-specific TAK1 knockout mice and examined whether ablation of T...
متن کاملChanges in Proteasome Structure and Function Caused by HAMLET in Tumor Cells
BACKGROUND Proteasomes control the level of endogenous unfolded proteins by degrading them in the proteolytic core. Insufficient degradation due to altered protein structure or proteasome inhibition may trigger cell death. This study examined the proteasome response to HAMLET, a partially unfolded protein-lipid complex, which is internalized by tumor cells and triggers cell death. METHODOLOGY...
متن کاملApoptosis following photodynamic tumor therapy: induction, mechanisms and detection.
As a treatment modality for malign and certain non-malignant diseases, photodynamic therapy (PDT) involves a two step protocol which consists of the (selective) uptake and accumulation of a photosensitizing agent in target cells and the subsequent irradiation with light in the visible range. Reactive oxygen species (ROS) produced during this process cause cellular damage and, depending on the t...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2005
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/135.5.1299