منابع مشابه
Mechanisms underlying hypoxia-induced neuronal apoptosis.
In vivo models of cerebral hypoxia-ischemia have shown that neuronal death may occur via necrosis or apoptosis. Necrosis is, in general, a rapidly occurring form of cell death that has been attributed, in part, to alterations in ionic homeostasis. In contrast, apoptosis is a delayed form of cell death that occurs as the result of activation of a genetic program. In the past decade, we have lear...
متن کاملTestosterone-induced neuronal apoptosis ELEVATED TESTOSTERONE INDUCES APOPTOSIS IN NEURONAL CELLS
ELEVATED TESTOSTERONE INDUCES APOPTOSIS IN NEURONAL CELLS Manuel Estrada*#, Anurag Varshney* and Barbara E. Ehrlich† Departments of Pharmacology and Cellular and Molecular Physiology, Yale University, New Haven, CT 06520, USA Running title: Testosterone-induced neuronal apoptosis * These authors contributed equally to this work and are listed alphabetically. †Corresponding author: Barbara E Ehr...
متن کاملHaloperidol-induced changes in neuronal activity in the striatum of the freely moving rat
The striatum is the main input structure of the basal ganglia, integrating input from the cerebral cortex and the thalamus, which is modulated by midbrain dopaminergic input. Dopamine modulators, including agonists and antagonists, are widely used to relieve motor and psychiatric symptoms in a variety of pathological conditions. Haloperidol, a dopamine D2 antagonist, is commonly used in multipl...
متن کاملCrocin prevents haloperidol-induced orofacial dyskinesia: possible an antioxidant mechanism
Objective(s):Long-term treatment with antipsychotics causes serious side effects such as tardive dyskinesia that characterized by abnormal movements in the orofacial region. Oxidative stress in the brain specific area is implicated in the pathophysiology of tardive dyskinesia. In this study the protective effect of crocin on haloperidol-induced orofacial dyskinesia was evaluated. Materials and ...
متن کاملOral administration of Ginkgolide B alleviates hypoxia-induced neuronal damage in rat hippocampus by inhibiting oxidative stress and apoptosis
Objective(s): The aim of this study is to explore the potential neuroprotective effects of Ginkgolide B (GB), a main terpene lactone and active component in Ginkgo biloba, in hypoxia-induced neuronal damage, and to further investigate its possible mechanisms.Materials and Methods: 54 Sprague-Dawley rats were randomly divided into three groups: the untreated control group (n=18); the hypoxia gro...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2008
ISSN: 0022-3042
DOI: 10.1046/j.1471-4159.2000.0752327.x