Half the Decade Over or Half to Go?

A decade of mycophenolate mofetil for lupus nephritis: is the glass half-empty or half-full?

The treatment of proliferative lupus nephritis (LN) can be staged as a period of intensive immunosuppressive therapy aimed at halting immunological injury (induction therapy) followed by a period of less aggressive maintenance therapy to consolidate the response. Maintenance therapy should be continued into the period of disease quiescence to decrease the number of fl ares and renal damage accr...

Half empty or half full?

Plane Strain Deformation of a Poroelastic Half-Space Lying Over Another Poroelastic Half-Space

The plane strain deformation of an isotropic, homogeneous, poroelastic medium caused by an inclined line-load is studied using the Biot linearized theory for fluid saturated porous materials. The analytical expressions for the displacements and stresses in the medium are obtained by applying suitable boundary conditions. The solutions are obtained analytically for the limiting case of undrained...

Synaptic Vesicles: Half Full or Half Empty?

The regulation of quantal size through pre- rather than postsynaptic mechanisms has recently received considerable attention as a potential mechanism for plasticity. Vesicular transporters catalyze the filling of synaptic vesicles with transmitter and are thus potential substrates for such presynaptic regulation. In this issue of Neuron, Prado et al. pursue this line of investigation and show t...

Half full or half empty VATS?

Cardiothoracic Surgeons of Great Britain and Ireland. Tom Treasure is responsible to the society for the collection and collation of these data and has a mandate from the society’s annual general meeting of its members to disseminate information based on the data. Contributors: AS, TT, and JvdM were responsible for study concept and design. TT and AS were responsible for acquisition of the data...