Haemorrhagic disease and vitamin K.

Vitamin K and haemorrhagic disease of the newborn.

Vitamin K in Prenatal Prevention and Postnatal Treatment of Haemorrhagic Disease of the Newborn.

Vitamin K is an essential in human nutrition for the maintenance of normal blood clotting function. It is involved in the synthesis of prothrombin and is directly related to the concentration of the latter in the circulating blood. We have (Kugelmass and Samuel, 1931) advanced the hypothesis of a dietary basis of the formation of clotting constituents, formulated 'clotting' and 'bleeding' diets...

Haemorrhagic diathesis in children associated with vitamin K deficiency.

A haemorrhagic diathesis is described in infants; this is preceded and accompanied by constitutional symptoms such as fever, diarrhoea, vomiting, anorexia, and pallor. These children had a severe coagulation abnormality, due to deficiency of vitamin-K-dependent coagulation factors, and it was corrected by administration of vitamin K. No conclusion could be drawn as to the aetiology of this cond...

Vitamin K Deficiency Disease

Vitamin Kdeficiency bleeding (VKDB) previously known as hemorrhagic disease of the newborn has been classified as Early (0-24hrs), Classic (2-7 days) and Late (1-6 months). Child birth following the maternal ingestion of anti-epileptic drugs such as Phenytoin, is liable to result in early VKDB as well as bone changes in the fetus. Other maternal risk factors for VKDB include medications such as...

Vitamin K and metabolic bone disease.

Originally, vitamin K was defined as a factor concerned with haemostasis, deficiency resulting in a haemorrhagic disease. After the initial discovery of phylloquinone in 1929, various compounds were described which all had “vitamin K activity,” that is, the ability to restore normal haemostasis in vitamin K deficient animals. It turned out that “vitamin K” is a group name for several related co...