H2O2 potentiates TNF-α cellular toxicity: reversal with propofol

Simvastatin Potentiates TNF-

TNF-α-308G/A polymorphism associated with TNF-α protein expression in patients with diabetic nephropathy.

AIMS This study was to clarify the regulated effects of TNF-α -308G/A polymorphism on TNF-α and investigate the relationship of -308G/A polymorphisms with diabetic nephropathy (DN) susceptibility. METHODS 86 DN patients and 94 healthy individuals were enrolled in our study. Polymerase chain reaction-sequence specific primer (PCR-SSP) detection technology was used to testify single nucleotide ...

Targeting TNF-α with a tetravalent mini-antibody TNF-TeAb

Mengyuan LIU*†, Xiangbin WANG†, Changcheng YIN†, Zhong ZHANG†, Qing LIN†, Yongsu ZHEN§ and Hualiang HUANG†‡1 *Faculty of Life Science, Hubei University, 430062 Wuhan, People’s Republic of China, †Beijing ABT Genetic Engineering Technology Co. Ltd., 102206 Beijing, People’s Republic of China, §The Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical S...

IL-4 induces ICAM-1 expression in human bronchial epithelial cells and potentiates TNF-α.

Interleukin (IL)-4 is thought to contribute to the Th2 type of immune response and hence the development of allergic reactions such as asthma. In asthmatic patients, the airway epithelium expresses increased amounts of the cell surface adhesion molecule intercellular adhesion molecule (ICAM)-1 (CD54). One cytokine capable of inducing ICAM-1 in airway epithelial cells, tumor necrosis factor-α (T...

Leptin potentiates Prevotella intermedia lipopolysaccharide-induced production of TNF-α in monocyte-derived macrophages

PURPOSE In addition to regulating body weight, leptin is also recognized for its role in the regulation of immune function and inflammation. The purpose of this study was to investigate the effect of leptin on Prevotella (P.) intermedia lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha production in differentiated THP-1 cells, a human monocytic cell line. METHODS LPS from P. ...