H-NOX regulation of c-di-GMP metabolism and biofilm formation in Legionella pneumophila

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H-NOX regulation of c-di-GMP metabolism and biofilm formation in Legionella pneumophila.

UNLABELLED Haem Nitric oxide/OXygen (H-NOX) binding domains are a family of haemoprotein sensors that are widespread in bacterial genomes, but limited information is available on their function. Legionella pneumophila is the only prokaryote found, thus far, to encode two H-NOX proteins. This paper presents data supporting a role for one of the L. pneumophila H-NOXs in the regulation of biofilm ...

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Legionellosis is mostly caused by Legionella pneumophila (Lp) and is defined by a severe respiratory illness with a case fatality rate ranging from 5 to 80%. In a previous study, we showed that a glycosaminoglycan (GAG)-binding adhesin of Lp, named Lcl, is produced during legionellosis and is unique to the L. pneumophila species. Importantly, a mutant depleted in Lcl (Δlpg2644) is impaired in a...

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ژورنال

عنوان ژورنال: Molecular Microbiology

سال: 2010

ISSN: 0950-382X,1365-2958

DOI: 10.1111/j.1365-2958.2010.07259.x