Gut microbiota sPARk vagus nerve excitation

The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis

The microbiota, the gut, and the brain communicate through the microbiota-gut-brain axis in a bidirectional way that involves the autonomic nervous system. The vagus nerve (VN), the principal component of the parasympathetic nervous system, is a mixed nerve composed of 80% afferent and 20% efferent fibers. The VN, because of its role in interoceptive awareness, is able to sense the microbiota m...

Intestinal microbiota impact sepsis associated encephalopathy via the vagus nerve

OBJECTIVE The pathogenesis of sepsis associated encephalopathy (SAE) remains poorly understood. Vagus nerve plays an important role in gut-microbiota-brain axis. This study aimed to investigate whether vague nerve is a key mediator of the impact of intestinal microbiota on SAE. METHODS Male rats were randomly divided into four groups (n=20): SHAM (SH) group, lipopolysaccharide (LPS) group, fe...

Gut Microbiota and Neuropsychiatric Disorders

Gut Bacteria, the Vagus Nerve and the Brain

There is now strong evidence from animal studies that gut microorganisms can activate the vagus nerve and that such activation plays a critical role in mediating effects on the brain and behaviour. The vagus can differentiate between commensal and potentially pathogenic bacteria even in the absence of overt inflammation and vagal afferent signals can induce both anxiogenic and anxiolytic effect...

Psychobiotics and Brain-Gut Microbiota Axis

Fermented foods containing probiotic bacteria have been used for many years to improve the health or treatment of some diseases. Nowadays, the Therapeutic properties of probiotics are becoming more and more obvious to everyone, insofar as in recent years, more attention has been paid to the potential relation between gut microbiota and mental health. Several studies have shown that intestinal m...