Gut Microbiome Composition Associated With Major Depressive Disorder and Sleep Quality

The microbiota–gut–brain axis plays a critical role in the pathogenesis of major depressive disorder (MDD) and related subclinical symptoms. However, studies on gut microbiota MDD are inconsistent, data MDD's effects sleep lacking. This study aimed to analyze composition quality patients with MDD. We performed 16S rRNA sequencing stool samples from 36 45 healthy controls (HC). Sleep was assessed using Pittsburgh Quality Index, severity Hamilton Depression Scale, insomnia Insomnia Severity Index. Forty-eight targets showed significant differences between HC. In MDD, six were associated depression, 11 quality, 3 severity. At genus level, Dorea simultaneously depression while Intestinibacter more closely problems. Coprococcus independent depression. conclusion, present findings enable better understanding relationship MDD-related Gut alterations may become potential biomarkers and/or treatment for