Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

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Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

Normal platelet function is critical to blood hemostasis and maintenance of a closed circulatory system. Heightened platelet reactivity, however, is associated with cardiometabolic diseases and enhanced potential for thrombotic events. We now show gut microbes, through generation of trimethylamine N-oxide (TMAO), directly contribute to platelet hyperreactivity and enhanced thrombosis potential....

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April 25, 2017 1671 CORRPONDENCE We previously showed gut microbial production of trimethylamine N-oxide (TMAO) from dietary nutrients like choline, lecithin, and L-carnitine is linked to the development of cardiovascular diseases.1–3 We also recently reported that plasma TMAO levels are associated with incident thrombotic event risk in subjects, and that TMAO both enhances platelet responsiven...

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ژورنال

عنوان ژورنال: Cell

سال: 2016

ISSN: 0092-8674

DOI: 10.1016/j.cell.2016.02.011