Gum pigmentation: an unusual adverse effect of sublingual immunotherapy

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Gum pigmentation: an unusual adverse effect of sublingual immunotherapy

Sublingual immunotherapy has gained acceptance amongst the paediatric community as it is very well tolerated and is safe. The adverse effects of this therapy is minimal consisting mainly of local side effects within the oral cavity such as itching of the mouth, swelling of the lips and less frequently abdominal pain, wheezing and urticaria has been described. This report is to highlight another...

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BACKGROUND Sublingual allergen immunotherapy is an effective treatment against allergic respiratory disease. Many studies have shown the safety of this type of therapy, although the factors that might affect the tolerability of high-dose sublingual immunotherapy have not been well established. The aim of this study was to determine the factors that affect the tolerability of sublingual allergen...

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An unusual palmoplantar pigmentation.

A 60 year old man had asymptomatic progressive pigmentation of the palms (fig 1), fingertips (fig 2), and soles for the last 20 years. Besides this, he had discoloration of his sclerae (fig 3). He was well but for low backache and joint pains of a few months’ duration. Histopathological examination of the skin lesion was diagnostic (fig 4). Questions (1) What is your diagnosis? (2) What are the...

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Uterine contractions: an unusual side effect of venom immunotherapy.

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Immunological mechanisms of sublingual immunotherapy.

Administration of allergen-specific immunotherapy by the oral route, sublingual immunotherapy (SLIT), has been shown to be effective, with an improved safety profile compared with subcutaneous administration. However, the precise mechanisms underlying the induction of immune tolerance by SLIT remain unclear. Contact of the allergen with the antigen-presenting cells in oral mucosa is likely to b...

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ژورنال

عنوان ژورنال: Asia Pacific Allergy

سال: 2014

ISSN: 2233-8276,2233-8268

DOI: 10.5415/apallergy.2014.4.3.177