Guanylyl cyclase crosstalk in spontaneously hypertensive rats
نویسندگان
چکیده
منابع مشابه
Downregulation of soluble guanylyl cyclase in young and aging spontaneously hypertensive rats.
Endothelial dysfunction, as observed in hypertension and atherosclerosis, is associated with a reduction in the bioavailability of endothelium-derived nitric oxide (NO). We tested the hypothesis that alterations in the soluble guanylyl cyclase (sGC) pathway may also contribute to the pathogenesis of hypertension. Therefore, we investigated the expression and activity of sGC in young (6 weeks) a...
متن کاملSpontaneously Hypertensive Rats
We have investigated whether differences seen in the pharmacological and morphological properties of mesenteric resistance vessels from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) controls are also present in vessels from young SHR and WKY rats in which there is little difference in blood pressure (BP). Segments of small arteries (lumen diameter 150 ̂ m) were taken ...
متن کاملSpontaneously Hypertensive Rats
The endothelium-dependent vascular relaxation to acetylcholine (ACh) in spontaneously hypertensive rats (SHR) may be impaired because of an imbalance of endothelium-derived relaxing factor and contracting factor. However, the role of the endothelium-dependent hyperpolarization remains undetermined. We examined the ACh-induced hyperpolarization and its contribution to relaxation in arteries of S...
متن کاملSpontaneously Hypertensive Rats
Previous studies demonstrate that bilateral renal denervation enhances urinary sodium excretion and delays the onset of hypertension in young (7-week-old) spontaneously hypertensive rats (SHR) maintained on ordinary laboratory chow. We interpret these data as suggesting that increased renal nerve activity in this model contributes to hypertension by causing excess sodium retention. More recent ...
متن کاملSpontaneously Hypertensive Rats
Intracellular calcium may be a mediator of insulin action in vascular smooth muscle cells. This study investigates effects of physiological concentrations of insulin on intracellular free calcium concentrations in primary unpassaged vascular smooth muscle cells derived from 3and 17-week-old normotensive rats (Wistar and Wistar-Kyoto) and spontaneously hypertensive rats (SHR). Underlying mechani...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2003
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(03)00485-0