Guanyl Cyclase, an Enzyme Catalyzing the Formation of Guanosine 3',5'-Monophosphate from Guanosine Triphosphate
نویسندگان
چکیده
منابع مشابه
Nonenzymatic formation of guanosine 3':5'-monophosphate from guanosine triphosphate.
We observed the nonenzymatic formation of guanosine 3’:5’-monophosphate (cyclic GMP) from GTP. The reaction was dependent upon heat and was accelerated by divalent cations and creatine phosphate. The formation of cyclic GMP was greater with increased incubation time, temperature, GTP concentration, and pH. All of the divalent cations tested (Mg2+, Mnz+, Ca2+, Ba2+, and Znzf) increased cyclic GM...
متن کاملAdenosine Triphosphate : Guanosine Monophosphate Phosphotransferase
Several laboratories have reported studies on individual enzymes that belong to the general class of adenosine triphosphate : nucleoside monophosphate phosphotransferases (EC 2.7.4.4), commonly termed nucleoside monophosphate kinases (l-7). Studies with partially purified enzyme preparations have indicated that a variety of nucleoside monophosphates can serve as alternative substrates for nucle...
متن کاملCyclic Guanosine Monophosphate
Since we have previously shown a direct inhibitory effect of platelet-activating factor (PAF) on Cl reabsorption in the medullary thick ascending limb of Henle's loop (TAL), the aim of this study was to extend this effect to the whole TAL and to further investigate the signaling pathway involved. In microperfused cortical TALs, PAF significantly decreased Cl reabsorption by 50.3±6.5%. On the on...
متن کاملThe Isolation of Guanosine Tetraphosphate from Commercially Available Preparations of Guanosine Triphosphate.
The isolation of adenosine tetraphosphate and pentaphosphate from samples of adenosine triphosphate has been reported by Marrian (1) and Sacks (2). The available evidence is consistent with a st,ructure in which the phosphate residues are linked by phosphoanhydride bonds to one another and are carried by the 5’-hgdroxyl group of the ribose moiety (l-4). During attempts to estimate guanosine tri...
متن کاملInteraction of guanosine nucleotides with elongation factor 2. II. Effect of ribosomes and magnesium ions on guanosine diphosphate and guanosine triphosphate binding to the enzyme.
The effects of ribosomes and Mg-2plus on the binding of GDP and GTP to elongation factor 2 (EF-2) have been studied by an improved filter-binding assay. Both ribosomes and Mg-2plus strongly inhibit the binding of GDP but have apparently no effect on the GTP binding to the enzyme. An apparent stimulation by ribosomes of GTP binding to EF-2 is time-dependent and parallels a concomitant increase o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1969
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)63473-8