Guanethidine-induced destruction of peripheral sympathetic neurons occurs by an immune-mediated mechanism

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Guanethidine-induced destruction of peripheral sympathetic neurons occurs by an immune-mediated mechanism.

Guanethidine, a guanidinium adrenergic neuron blocking agent, when administered chronically at high doses to newborn or adult rats, causes destruction of peripheral sympathetic neurons. Neuronal destruction is preceded by small cell infiltration of the sympathetic ganglia and is suggestive of an immunologically mediated mechanism. Immune reconstitution experiments were carried out to demonstrat...

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ژورنال

عنوان ژورنال: The Journal of Neuroscience

سال: 1983

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.03-04-00714.1983