GTP Cyclohydrolase I Gene Expression in the Brains of Male and Female hph-1 Mice
نویسندگان
چکیده
منابع مشابه
Differential effects of eNOS uncoupling on conduit and small arteries in GTP-cyclohydrolase I-deficient hph-1 mice.
In the present study, we used the hph-1 mouse, which displays GTP-cyclohydrolase I (GTPCH I) deficiency, to test the hypothesis that loss of tetrahydrobiopterin (BH(4)) in conduit and small arteries activates compensatory mechanisms designed to protect vascular wall from oxidative stress induced by uncoupling of endothelial nitric oxide synthase (eNOS). Both GTPCH I activity and BH(4) levels we...
متن کاملImpaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain
BACKGROUND GTP cyclohydrolase 1 (GTP-CH1), the rate-limiting enzyme in the synthesis of tetrahydrobiopterin (BH4), encoded by the GCH1 gene, has been implicated in the development and maintenance of inflammatory pain in rats. In humans, homozygous carriers of a "pain-protective" (PP) haplotype of the GCH1 gene have been identified exhibiting lower pain sensitivity, but only following pain sensi...
متن کاملCloning and developmental expression of zebrafish GTP cyclohydrolase I
GTP cyclohydrolase I (GCH) catalyses the conversion of GTP to dihydroneopterin triphosphate, initiating the pteridine pathway. The final product tetrahydrobiopterin (H4biopterin) is the cofactor for neurotransmitter synthesis and for tyrosine supply during melanogenesis. Sepiapterin accumulates as a pigment. We cloned the zebrafish gch cDNA, which encodes a protein highly homologous to other ve...
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چکیده هدف اصلی تحقیق حاضر مطالعه و بررسی رابطه بین خودکارامدی شنیداری با درک شنیداری بود.همچنین رابطه درک شنیداری وخودکارآمدی شنیداری با جنسیت و رابطه خودکارامدی شنیداری با سن نیز مورد بررسی قرار گرفت.تعداد شصت زبان اموز-سی دختر و سی پسر- کانون زبان ایران در مرکز خرم آباد به صورت تصادفی انتخاب شدند. روشهای به کار رفته در جمع اوری داده ها عبارت بودند ازبرسشنامه خودکارآمدی و تست درک شنیداری لانگ...
15 صفحه اولCytokines stimulate GTP cyclohydrolase I gene expression in cultured human umbilical vein endothelial cells.
In vascular endothelial cells, tetrahydrobiopterin serves as an essential cofactor required for enzymatic activity of nitric oxide synthase. GTP cyclohydrolase I is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin. Previous studies have demonstrated that proinflammatory cytokines stimulate production of tetrahydrobiopterin in endothelial cells. Long-term regulation of GTP cyc...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 1999
ISSN: 0022-3042
DOI: 10.1046/j.1471-4159.1999.0720757.x