GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration
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چکیده
منابع مشابه
GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration
Macroautophagy is a catabolic process, in which portions of cytoplasm or organelles are delivered to lysosomes for degradation. Emerging evidence has indicated a pathological connection between axonal degeneration and autophagy. However, the physiological function and induction mechanism of autophagy in axons remain elusive. We herein show that, through activation of BECLIN1, glycogen synthase ...
متن کاملSpecific phospholipid scramblases are involved in exposure of phosphatidylserine, an “eat-me” signal for phagocytes, on degenerating axons
Axonal degeneration is a key pathological feature of several neurological disorders. Emerging evidence has suggested a pathological connection between axonal degeneration and autophagy, a lysosomal degradation pathway. We recently reported that GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote axonal degeneration. GSK3B-MCL1 pathway affects ATP production locally in d...
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Starvation induces autophagy to preserve cellular homeostasis in virtually all eukaryotic organisms. However, the mechanisms by which starvation induces autophagy are not completely understood. In mammalian cells, the antiapoptotic protein, Bcl-2, binds to Beclin 1 during nonstarvation conditions and inhibits its autophagy function. Here we show that starvation induces phosphorylation of cellul...
متن کاملThe slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice.
Axonal dystrophy is the hallmark of axon pathology in many neurodegenerative disorders of the CNS, including Alzheimer's disease, Parkinson's disease and stroke. Axons can also form larger swellings, or spheroids, as in multiple sclerosis and traumatic brain injury. Some spheroids are terminal endbulbs of axon stumps, but swellings may also occur on unbroken axons and their role in axon loss re...
متن کاملThe slow Wallerian degeneration gene, Wld, inhibits axonal spheroid pathology in gracile axonal dystrophy mice
Correspondence: Dr Michael Coleman, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK E-mail: [email protected] *W. Mi and B. Beirowski contributed equally to this work ZMMK and Institute for Genetics and Department of Anatomy I, University of Cologne, Cologne, Germany, Division of Neuroscience, University of Edinburgh, Edinburgh, The Babraham Institute, Babraham, Cambridge, UK,...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2017
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201606020