Growth retardation and familial thyroxine-binding globulin deficiency.

Growth retardation and thyroxine-binding globulin deficiency.

Familial thyroxine-binding globulin deficiency.

Genetically determined thyroxine-binding globulin deficiency is described in two families in the United Kingdom. All subjects in both pedigrees were euthyroid. Transmission was by sex-linkage; males showed low serum protein bound iodine and high thyroxine (T4) resin uptake due to complete absence of serum thryroxine-binding globulin; females were less severely affected. The distinctive biochemi...

Growth Retardation and Thyroxine-binding Globulin

Javert, C. T. (1942). Erythroblastosis neonatorum. An obstetricalpathological study of 47 cases. Surgery, Gynecology and Obstetrics, 74, 1. Kamicki, J. (1968). Results and hazards of prenatal transfusion. Journal of Obstetrics and Gynaecology of the British Commonwealth, 75, 1209. Kitchen, W. H. (1970). Birth weight of infants with Rhesus incompatibility. Australian and New Zealand journal of O...

Familial thyroxine-binding globulin deficiency: search for linkage with Xg blood groups.

Metabolism of thyroxine-binding globulin in man. Abnormal rate of synthesis in inherited thyroxine-binding globulin deficiency and excess.

It has been previously suggested that inherited thyroxine-binding globulin (TBG) abnormalities in man may be due to mutations at a single X-chromosome-linked locus controlling TBG synthesis. However, abnormalities in TBG degradation have not been excluded. The availability of purified human TBG and its successful labeling with radioiodide allowed us to examine such possibility. Human TBG was pu...