Growth hormone treatment in non-growth hormone-deficient children

Growth hormone treatment in non-growth hormone-deficient children

Until 1985 growth hormone (GH) was obtained from pituitary extracts, and was available in limited amounts only to treat severe growth hormone deficiency (GHD). With the availability of unlimited quantities of GH obtained from recombinant DNA technology, researchers started to explore new modalities to treat GHD children, as well as to treat a number of other non-GHD conditions. Although with so...

Optimization of growth hormone therapy in growth hormone deficient children.

Successful treatment with human growth hormone (hGH) was initially reported by Raben in 19581. Although itis well established that pituitary derived or biosynthetic hGH increases the growth rate in growth hormone deficient children, many patients that were treated in the early days have not reached their target height, or attained adult height below the third percentile of population standards ...

effects of growth hormone replacement therapy on thyroid function tests in growth hormone deficient children

there are numerous, often contradictory reports on the effect of growth hormone (gh) therapy on thyroid function. these reports prompted us to evaluate the impact of gh therapy on thyroid function in previously euthyroid children with gh deficiency. twenty five clinically and biochemically euthyroid children with gh deficiency were studied. a thyroid profile (t4, free t4, t3 and tsh) was perfor...

Differential growth and maturation in idiopathic growth-hormone-deficient children.

This study describes and compares the growth and maturation of idiopathic growth hormone deficiency (IGHD) and evaluates the potential effects of growth hormone therapy. The sample includes 40 idiopathic growth-hormone-deficient children grouped according to duration of growth hormone replacement therapy. Somatic and craniofacial development, skeletal maturation and dental maturation were evalu...

evaluation of insulin-like growth factor-1 and its impact on growth hormone therapy in growth hormone-deficient indian children