منابع مشابه
Rab GEFs and GAPs.
Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs), and a family of GTP-hydrolysis activating proteins (GAPs) containing the conserved TBC domain. Recent structural and cell biological studies shed new light on the mechanisms of Rab GEF and GAP action, and the cellular tr...
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We consider a growth model proposed by Matsuyama [K. Matsuyama, Growing through cycles, Econometrica 67 (2) (1999) 335–347] in which two sources of economic growth are present: the mechanism of capital accumulation (Solow regime) and the process of technical change and innovations (Romer regime). We will shown that no stable cycle can exist, except for a fixed point and a cycle of period two. T...
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Within blood vessels, endothelial cellâ€"cell and cellâ€"matrix adhesions are crucial to preserve barrier function, and these adhesions are tightly controlled during vascular development, angiogenesis, and transendothelial migration of inflammatory cells. Endothelial cellular signaling that occurs via the family of Rho GTPases coordinates these cell adhesion structures through cytoskeletal remo...
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Heavy-metal pollution represents an important environmental problem due to the toxic effects of metals, and their accumulation throughout the food chain leads to serious ecological and health problems. Metal remediation through common physico-chemical techniques is expensive and unsuitable in case of voluminous effluents containing complexing organic matter and low metal contamination. Biotechn...
متن کاملUsing GEFs to deorphanize odorant receptors.
Odorant perception is initiated when odorants activate unique combinations of odorant receptors (ORs) expressed in the cilia of olfactory sensory neurons in the nose (Buck and Axel 1991; Malnic et al. 1999). One of the greatest challenges in the olfactory science is to correlate ORs with their ligands (to deorphanize the ORs). The determination of OR– ligand pairs should reveal how the OR famil...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2005
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc1574