Group-specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D.
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چکیده
منابع مشابه
Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety.
For adults, the 5-microg (200 IU) vitamin D recommended dietary allowance may prevent osteomalacia in the absence of sunlight, but more is needed to help prevent osteoporosis and secondary hyperparathyroidism. Other benefits of vitamin D supplementation are implicated epidemiologically: prevention of some cancers, osteoarthritis progression, multiple sclerosis, and hypertension. Total-body sun ...
متن کاملKidney disease and vitamin D levels: 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and VDR activation
A normal vitamin D status is essential for human health. Vitamin D deficiency is a recognized risk factor for all-cause mortality in normal individuals and in chronic kidney disease (CKD) patients. The link between vitamin D deficiency and death is a defective activation of the vitamin D receptor (VDR) by 1,25-dihydroxyvitamin D (calcitriol, the vitamin D hormone) to induce/repress genes that m...
متن کاملSerum 25-hydroxyvitamin D (25-OH-D) in obese adolescents.
BACKGROUND There is increasing evidence that vitamin D deficiency is common and has been associated with several non-bone related outcomes, including insulin resistance, type 2 diabetes and cardiovascular disease. The influences of gender, puberty, and adiposity on serum hydroxyvitamin D (25-OH-D) levels and the relationship between 25-OH-D and insulin resistance in obese children were studied....
متن کاملMeta - analyses of vitamin D intake , 25 - hydroxyvitamin D status , vitamin D receptor 1 polymorphisms and colorectal cancer risk
3 Mathilde Touvier, Doris SM Chan, Rosa Lau, Dagfinn Aune, Rui Vieira, Darren C Greenwood, 4 Ellen Kampman, Elio Riboli, Serge Hercberg, Teresa Norat 5 Affiliations: 6 1 Department of Epidemiology and Biostatistics, School of public health, Imperial College London, 7 United Kingdom 8 2 Nutritional Epidemiology Unit, UREN (Inserm/Inra/Cnam/Paris13 University), CRNH IdF, Bobigny, 9 France 10 3 Bi...
متن کاملMeta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk.
BACKGROUND Our objective was to conduct a systematic review and meta-analysis of prospective studies on colorectal cancer (CRC) and vitamin D intake and 25-hydroxyvitamin D status, as part of the World Cancer Research Fund Continuous Update Project. We also aimed at conducting meta-analysis of all studies on CRC and vitamin D receptor (VDR) single-nucleotide polymorphisms. METHODS Relevant st...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1975
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.72.6.2076