Group I metabotropic glutamate receptors participate in homocysteine-evoked neurotoxicity
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چکیده
منابع مشابه
Group I metabotropic glutamate receptors at GABAergic synapses in monkeys.
Recent data showed that group I metabotropic glutamate receptors (mGluRs) are located perisynaptic to the postsynaptic specializations of asymmetric glutamatergic synapses in the cerebellum and hippocampus in rats. In the present study, we used immunogold labeling to elucidate the subsynaptic localization of group I mGluRs (mGluR1a and mGluR5) in the internal and external segments of the globus...
متن کاملGroup I Metabotropic Glutamate Receptors (mGlu1 and mGlu5)
The metabotropic glutamate (mGlu) receptors are a family of eight G protein-coupled receptors that modulate cell excitability and synaptic transmission in the nervous system. Group I mGlu receptors are generally coupled to Gq stimulation of phospholipase C and the release of intracellular calcium. The physiologic effects of group I mGlu receptors in the brain are diverse and highlight the impor...
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A discriminating pharmacophore model for noncompetitive metabotropic glutamate receptor antagonists of subtype 1 (mGluR1) was developed that facilitated the discovery of moderately active mGluR1 antagonists. One scaffold was selected for the design of several focused libraries where different substitution patterns were introduced. This approach facilitated the discovery of potent mGluR1 antagon...
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Metabotropic glutamate receptors (mGluRs) couple to heterotrimeric G-proteins and regulate cell excitability and synaptic transmission in the CNS. Considerable effort has been focused on understanding the cellular and biochemical mechanisms that underlie regulation of signaling by G-proteins and their linked receptors, including the mGluRs. Recent findings demonstrate that regulators of G-prote...
متن کاملExcitation of cerebellar interneurons by group I metabotropic glutamate receptors.
Cerebellar basket and stellate neurons (BSNs) provide feed-forward inhibition to Purkinje neurons (PNs) and thereby play a principal role in determining the output of the cerebellar cortex. During low-frequency transmission, glutamate released at parallel fiber synapses excites BSNs by binding to AMPA receptors; high-frequency transmission also recruits N-methyl-d-aspartate (NMDA) receptors. We...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2003
ISSN: 0022-3042,1471-4159
DOI: 10.1046/j.1471-4159.85.s2.15_7.x