Group B Streptococcus: global incidence and vaccine development
نویسندگان
چکیده
منابع مشابه
Incidence and severity of invasive Streptococcus pneumoniae, group A Streptococcus, and group B Streptococcus infections among pregnant and postpartum women.
BACKGROUND The epidemiology of streptococcal infection in pregnant and postpartum women is poorly described in recent literature. We used data from multistate surveillance for invasive Streptococcus pneumoniae, group A Streptococcus (GAS), and group B Streptococcus (GBS) infections to estimate disease incidence and severity in these populations. METHODS Cases were reported through the Centers...
متن کاملStatus of group B streptococcal vaccine development
Streptococcus agalactiae (group B streptococcus, GBS) is a leading causal organism of neonatal invasive diseases and severe infections in the elderly. Despite significant advances in the diagnosis and treatment of GBS infections and improvement in personal hygiene standards, this pathogen is still a global health concern. Thus, an effective vaccine against GBS would augment existing strategies ...
متن کاملGroup B streptococcus pullulanase crystal structures in the context of a novel strategy for vaccine development.
The group B streptococcus type I pullulanase (SAP) is a class 13 glycoside hydrolase that is anchored to the bacterial cell surface via a conserved C-terminal anchoring motif and involved in alpha-glucan degradation. Recent in vitro functional studies have shown that SAP is immunogenic in humans and that anti-SAP sera derived from immunized animals impair both group A and group B streptococcus ...
متن کاملTemporal Changes in Invasive Group B Streptococcus Serotypes: Implications for Vaccine Development
INTRODUCTION There is a paucity of longitudinal data on the serotype-specific burden of invasive group B Streptococcus (GBS) disease from low-middle income countries, which could inform selection of vaccine epitopes. METHODS From 2005 to 2014, infants less than 90 days of age with invasive GBS disease were identified through sentinel laboratory and hospital admission surveillance at Chris Han...
متن کاملInvestigation of Betahemolytic Streptococcus Group B in Natural Vaginal Flora
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ژورنال
عنوان ژورنال: Nature Reviews Microbiology
سال: 2006
ISSN: 1740-1526,1740-1534
DOI: 10.1038/nrmicro1552