Griffonia simplicifolia I: Fluorescent tracer for microcirculatory vessels in nonperfused thin muscles and sectioned muscle
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Griffonia simplicifolia I: fluorescent tracer for microcirculatory vessels in nonperfused thin muscles and sectioned muscle.
Previous studies on mice have revealed that the Griffonia simplicifolia I (GSI) lectin selectively binds to capillaries in a number of microvascular beds. These observations suggest that the lectin might be a suitable microvascular marker for physiological studies of skeletal muscle, particularly when fluorescent visualization of vessels is desired independently of their perfusion status. Since...
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Commonly used methods for assessing reductions in microvascular density (rarefaction) in hypertension detect only perfused microvessels. In the present study, samples of cremaster and spinotrapezius muscles were taken from rats with chronic (4-week) reduced renal mass hypertension and normotensive sham-operated control rats, as well as from 12-week-old spontaneously hypertensive rats and their ...
متن کاملLectins from Griffonia simplicifolia seedsH
The physical-chemical and carbohydrate binding specificity of Griffonia simplicifolia I (GS I) isolectins, one of the 4 lectins isolated from Griffonia simplicifolia seeds, are described. Association constants for the binding of methyl αand β-D-galactopyranoside and methyl 2-acetamido-2-deoxy-α-D-galactopyranoside to the A4, A2 B2 and B4 isolectins are reported. Precipitation reactions of the G...
متن کاملPurification and Characterization of Griffonia simplicifolia Leaf
Leaves from mature Griffonia supficifolia plants were examined for the presence of leaf lectins possessing sugar binding specificities similar to the four known seed lectins (GS-I, GS-II, GS-III, GS-IV). Three (GS-I, -II, -IV) of the four known G. sinpIicifofia seed lectins were present in the leaves. Leaf G. simplicifolia lectins I and IV were similar to the respective seed lectins. Leaf GS-II...
متن کاملInhibition of Ehrlich ascites tumor cell growth by Griffonia simplicifolia I lectin in vivo.
Griffonia (Bandeiraea) simplicifolia I (GS I) seeds contain a family of alpha-D-galactopyranosyl-binding isolectins which strongly agglutinate Ehrlich ascites tumor cells due to the presence of this determinant sugar on their cell surface glycoproteins. Administration of GS I lectin (100 micrograms/day or 300 micrograms on alternate days, i.p.) inhibits the growth of Ehrlich tumor cells in vivo...
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ژورنال
عنوان ژورنال: Microvascular Research
سال: 1988
ISSN: 0026-2862
DOI: 10.1016/0026-2862(88)90022-2