Green tea catechin epigallocatechin gallate alleviates high‐fat diet‐induced obesity in mice by regulating the gut–brain axis

Plant polyphenols have gained attention in recent years because of their potential to alleviate obesity and metabolic syndrome, protect neurological function, maintain intestinal function. Here, we evaluated the effect green tea catechin epigallocatechin gallate (EGCG) suppress obesity, inflammation, regulate hypothalamic neurotransmitters high-fat diet mice. Obese male C57BL/6J mice were gavaged with 25, 50, or 100 mg/kg·body weight (bw) EGCG water per day for 6 weeks. The results demonstrated that significantly reduced bw, fat accumulation, liver steatosis. also modulated such as dopamine 5-HTP. Besides, attenuated expression colonic inflammatory factors barrier damage, increased gut microbial abundance genus Alloprevotella, short-chain fatty acids, downregulated transcription factors. suggest may related disorders through gut–brain interaction.