Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy
نویسندگان
چکیده
منابع مشابه
Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth
Quercetin and 2-Methoxyestradiol (2-ME) are promising anti-cancer substances. Our previous in vitro study showed that quercetin synergized with 2-Methoxyestradiol exhibiting increased antiproliferative and proapoptotic activity in both androgen-dependent LNCaP and androgen-independent PC-3 human prostate cancer cell lines. In the present study, we determined whether their combination could inhi...
متن کاملMOLECULAR MECHANISM UNDERLYING QUERCETIN INDUCED APOPTOSIS BY insilico ANALYSIS and in PROSTATE CANCER PC-3 CELLS
The study was aimed to investigate the molecular mechanisms underlying triggering of apoptosis by quercetin using in silico analysis. The mechanism of binding of quercetin with NF-kB and other apoptotic proteins like BCL2 and BCLXL was analyzed in silico using Schrodinger suite 2009.Quercetin was found to exhibit high-affinity binding resulting from greater intermolecular forces between the lig...
متن کاملGreen tea and prostate cancer: from bench to clinic.
Green tea, the most popular beverage next to water, is a rich source of tea catechins and has potential to be developed as a chemopreventive agent for prostate cancer. For centuries it has been used in traditional medicine in Far-East countries. Male populations in these countries where large quantities of green tea are consumed on regular basis have the lowest incidence of prostate cancer. In ...
متن کاملModulation of cancer chemotherapy by green tea.
Biochemical modulation has played an important role in the development of cancer chemotherapy. We have directed our attention to the intake of common beverages and investigated the effects of green tea and tea components on the antitumor activity of doxorubicin. We carried out the combined treatment of toxorubicin and green tea on Ehrlich ascites carcinoma tumor-bearing mice. The oral administr...
متن کاملSilibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft.
Chemoprevention is an upcoming approach to control cancer including prostate cancer (PCa). Here, we studied the efficacy and associated mechanisms of a chemopreventive agent silibinin against ectopically growing and established advanced human prostate carcinoma PC-3 tumor xenografts in athymic nude mice. Dietary silibinin (0.5%, w/w) did not show any adverse health effect in mice. In first prot...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental & Clinical Cancer Research
سال: 2016
ISSN: 1756-9966
DOI: 10.1186/s13046-016-0351-x